康方生物公布，公司的合作伙伴Summit Therapeutics Inc.已确定依沃西(PD-1/VEGF)即将启动在非小细胞肺癌(NSCLC)领域临床III期试验的首两个适应症。
公告称，依沃西联合化疗治疗表皮生长因子受体(EGFR)突变的、接受过第叁代EGFR酪氨酸激酶抑制剂(TKI)治疗后进展的局部晚期或转移性非鳞状非小细胞肺癌。HARMONi是一项全球多中心、随机、双盲III期临床试验。
HARMONi临床试验已在美国首例患者给药。HARMONi将在美国、加拿大、欧洲和中国总计入组超400位受试者，在中国的部分称为AK112-301。本公司负责在中国的受试者入组，此部分已于前期完成;Summit将会负责在美国、加拿大和欧洲的受试者入组。依沃西联合化疗一线治疗转移性鳞状非小细胞肺癌，Summit计划将在2023年下半年完成HARMONi-3试验的首例病人给药。
于2022年12月6日，康方生物与Summit订立合作及许可协议，并授予Summit于美国、加拿大、欧洲及日本开发及商业化其突破性双特异性抗体依沃西(PD-1/VEGF,AK112)的独家许可权。
来源：康方生物
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